We are interested in understanding the environmental factors that modulate the function of cardiac electrophysiology.
Main Research Areas
Inflammatory signaling in the pathogenesis of atrial fibrillation (AF).
AF is the most common cardiac arrhythmia in adults with an increasing prevalence. Several projects are designed to investigate the mechanistic link between risk factors and AF pathophysiology. Among them, inflammasome signaling is a central focus.
Protein control and the development of atrial myopathy
We recently identified FK506 binding protein 5 (FKBP5) as a novel molecular player in atrial cardiomyopathy. A number of future research directions arise and may provide fresh opportunities for AF treatment and prevention.
Novel gene associated with cardiac arrhythmia – TANGO2
TANGO2-deficiency disorder (TDD) is a rare disorder caused by mutations in the TANGO2 gene. Affected individuals experience arrhythmias. The molecular mechanisms underlying the development of cardiac arrhythmias in the context of TDD remain elusive. Our goals are to understand the function of TANGO2 in cardiomyocytes and elucidate the molecular underpinnings of arrhythmia development in the Tango2 knockout mouse model.
Epigenetic regulation of cardiac conduction disorder (CCD).
CCD is very common in patients with heart failure/cardiomyopathy or with a genetic cause. Patients with severe CCD usually require pacemaker implantation. Understanding the molecular underpinnings of various forms of CCD may help to develop new therapies for patients suffering from CCD.
Li lab is funded by research grants from the National Institutes of Health ( R01HL136389, R01HL163277, R01HL164838; PI: Li) and the American Heart Association.
For complete publication, please check the NCBI bibliography